PHLPP1 and Anxiety: More recently, Shimizu et al. reported that the suprachiasmatic nucleus circadian oscillatory protein (SCOP) mediates the circadian regulation of long-term memory formation by local clocks in the hippocampus (Shimizu et al., 2016), and Nakano et al., found that the same molecule regulates the circadian expression of anxiety-like behavior under the control of local clocks in the basolateral amygdala (Nakano et al., 2016).