Although EAT thickening could be related to other cardiomyopathies such as ischemic cardiac disease, an enlargement of EAT has been observed by 2D-Echo-Döppler in both T1DM [49] and T2DM [50] patients in correlation with HF and cardiac biomarkers (i.e., BNP, troponin-T and C-reactive protein). This evidence concerns the gene NPPB and type 1 diabetes mellitus.