Finally, the timing in which the study was conducted is also different: while in the Correa et al. paper, the impact of tPA injection was assessed in the subacute phase (1 day post ischemia), in the present study, histological analysis were performed in subacute and chronic phases (up to 21dpi), which enables observing tissue regeneration, in particular OPC migration. Here, PLAT is linked to ischemia.