The top 3 sites that showed the greatest magnitude of differences when comparing ME/CFS GC-Hypersensitive to GC-Typical subjects (ME/CFS and Controls) were corresponded to GSTM1 (14.3% increase in methylation), MYO3B (13.7% increase), and GSTM5 (12.0% increase; Fig. 4). Here, GSTM5 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.