DAPK1 and neoplasm: As a consequence of the reduced methylation level, upregulation of DAPK1 mRNA expression was observed in mock tumor cells after demethylation treatment (Fig. 8c) whereas no further DAPK1 expression was shown in ITIH5 clone #4 harboring already an unmethylated DAPK1 promoter region as shown in Fig. 7d.