MM cells secrete EVs containing miR-146a into MSC and the overexpression of miR-146a in MSC elevates secretion of several cytokines and chemokines including CXCL1, IL-6, IL-8, IP-10, MCP-1, and CCL-5, enhancing MM cell viability and migration as a result, which expands our knowledge of mutual communication between cells mediated by EV-associated miRNAs [25]. This evidence concerns the gene CXCL1 and Miyoshi myopathy.