PTK2 and neoplasm: To gain insights into the molecular basis of apoptosis KCNMA1-modulated, the downstream target genes were characterized through cBioPortal for Cancer Genomics (Additional file 3: Figure S3) and found that the PTK2 gene involved in FAK apoptosis pathways may be correlated with KCNMA1. Firstly, we found that the PTK2 was significantly high expression in tumor tissues than paired normal tissues (Fig. 4a).