Considering the strong association between TRAF6 and activations of both AKT and TAK1 pathways, and their implications on apoptosis and cell proliferation as well as a possible therapeutic approach for treatment of cancer, we employed computational docking to identify small molecules that can specifically bind with the RING domain of TRAF6 and could compete with the binding of its natural ligand Ubc13. The gene discussed is UBE2N; the disease is cancer.