ZFP36L2 and acute lymphoblastic leukemia: Conditional KO of Zfp36l1 and Zfp36l2 in the T cell lineage leads to the development of T cell acute lymphoblastic leukemia.19 Prior to the onset of malignancy Zfp36l1 and Zfp36l2 play roles in early T cell development that are very similar to those in B cell development.