As mentioned above, SOD mimetics not only have been reported to provide radioprotection in animal models, they have been shown to be radio- and chemo- sensitizers, as they radio- sensitize treatments in head and neck tumors in mice [19], brain glioma mouse model [41] and a 4T1 mouse breast cancer xenograft model [42]. The gene discussed is SOD1; the disease is head and neck neoplasm.