Previous studies establishing mouse models of ZIKV infection have primarily been performed in immunocompromised mice; for example, via intracranial infection of suckling mice or in mice deficient in the interferon (IFN)-α/β receptor (IFNAR) or both IFNAR and the IFN-γ receptor (IFNGR) [2, 11–14]. Here, IFNGR1 is linked to Zika virus infectious disease.