Furthermore, antigen-experienced CD8+ T cells significantly down-regulate CD62L (L-selectin) (Fig 7G–7I), a lymph node homing marker that is characteristic of central memory CD8+ T cells [35], and ZIKV infection results in significantly more granzyme B (an important cytolytic molecule) expression on a per-cell basis than mock-infected mice (Fig 7J and 7K) at the peak of the T cell response. This evidence concerns the gene GZMB and Zika virus infectious disease.