Similar to what we observed in the peripheral blood, ZIKV infection induces a robust CD8+ T cell response with a significant increase in the proportion of antigen-experienced CD8+ T cells compared to UV-inactivated virus or mock-infection (41% versus 7% and 8% respectively, Fig 4F–4I), resulting in an approximately eight-fold increase in total number of CD8αloCD11ahi CD8+ T cells (Fig 4J). Here, CD8A is linked to Zika virus infectious disease.