The fourth newly identified patient (ANIRIDIA-070) was a sporadic case of aniridia with developmental delay, in which WAGR-array evidenced the presence of a large deletion of 11.6 Mb (Table 1, Fig 3), affecting 38 genes and including PAX6, WT1and BDNF, this last gene is responsible for the obesity in the WAGRO syndrome [MIM#612469; WAGR with Obesity]. The gene discussed is BDNF; the disease is obesity due to melanocortin 4 receptor deficiency.