To understand the roles in tumour pathobiology [22], here, we conducted a hypothesis-driven case-control study to identify four nsSNPs (rs10823607, rs12774070, rs4747096, and rs61537157; Table 1) in ADAMTS14 that are damaging for protein function, and these were studied with the environmental carcinogens to evaluate HCC susceptibility. The gene discussed is ADAMTS14; the disease is neoplasm.