Our findings point to the role of variant rs12774070 in the TSR domain near the glycosylation site that may affect the TSR domain and can alter the cell-surface association and sequential processing mechanisms of ADAMTS14. We presented additional evidence in HCC, as elevated ADAMTS14 gene expression was associated with more aggressive cancers and poorer clinical outcomes. The gene discussed is ADAMTS14; the disease is hepatocellular carcinoma.