HSPG2 and laryngotracheoesophageal cleft: The percentage of CD4+HLA-DR+ cells (referred to expression of HLA-DR) among CD4+ cells and that of CD8+ HLA-DR+ cells (also referred to expression of HLA-DR) among CD8+ T cells were elevated from patients with CHB, those with HBV-LC, to those with HBV-PLC (Fig 4).