Similarly, we further showed the concentrations of T lymphocytes, B cell, NK cells, CD4+ T cells and CD8+ T cells were decreased from patients with CHB, those with HBV-LC to those with HBV-PLC, and were significantly reduced in patients with HBV-PLC compared with those in patients with CHB. Here, HSPG2 is linked to laryngotracheoesophageal cleft.