As shown in Fig 2, the concentrations of CD3+ T lymphocytes, NK cells, B cells, CD4+ T cells and CD8+ T cells were decreased from patients with CHB, those with HBV-LC to those with HBV-PLC, and were significantly decreased in patients with HBV-LC and those with HBV-PLC compared with those with CHB (all P<0.05). Here, CD8A is linked to laryngotracheoesophageal cleft.