Approximately, a 2-fold increase of the expression profiles of fibronectin (Fig 4B), THBS2 (Fig 4C), COL1A2 (Fig 4D) COL3A1 (Fig 4E) mRNAs was observed in the presence of TGF-β1 or its combination with PFD when compared to control values. This evidence concerns the gene COL3A1 and polyostotic fibrous dysplasia.