An evaluation of the effect of the culinary Pleurotus ostreatus and P. cystidiosus mushrooms (consumed as freeze-dried powders at a dose of 50 mg/kg/body weight) in healthy human volunteers and type 2 diabetic patients showed: (a) a reduction in fasting and postprandial serum glucose levels of healthy volunteers; and (b) a reduction in postprandial serum glucose levels and increased serum insulin levels of type 2 diabetic patients [167]. Here, INS is linked to type 2 diabetes mellitus.