TGM2 and Abnormal intestine morphology: The common denominator for all subjects with CD is the presence of a variable combination of gluten-dependent clinical manifestations, specific autoantibodies (anti-tissue transglutaminase [TG]2, anti-endomysium [EMA] antibodies), HLA-DQ2, and/or DQ8 haplotypes, and different degrees of enteropathy, ranging from lymphocytic infiltration of the epithelium to complete villous atrophy [53].