ANXA5 and colorectal carcinoma: The cytotoxic activity and apoptosis induction of oridonin have been reported in several CRC cell lines including HT-29, HCT116, SW480, and SW620.16, 28, 30, 31, 32 But a very interesting finding grabbed our attention that although clear anti-proliferative activity was observed both in vitro and vivo, no typical apoptosis phenomenon was observed in SW480 cells, whereas clear apoptosis was detected in RKO cells using flow cytometry with Annexin V-FITC/PI labeling (Figure 1c).