GLUT1 is one of the most important regulators of glucose import, shows variable levels in many tissues and is believed to be responsible for basal glucose uptake,24 whereas MCT1 plays a major role in transport of lactate, pyruvate, and other short-chain monocarboxylates across the membrane in a freely reversible manner.43 Thus, our results indicated that oridonin can block both energy supply and lactate export through the regulation of GLUT1 and MCT1 in CRC cells. The gene discussed is SLC16A1; the disease is colorectal carcinoma.