Results indicated that cell death rate is upregulated with oridonin concentration in both SW480 and RKO cells, but no typical phenotype of apoptosis was observed in p53-mutated CRC cell SW480, similar results were also detected in another p53-mutated CRC cell HCT-15 (Supplementary Figure 1), whereas in p53 wild-type (WT) CRC cell RKO showed classical apoptosis (Figure 1c). This evidence concerns the gene TP53 and colorectal carcinoma.