12, 13 Oridonin treatment had multiple effects such as inhibition of proliferation and induction of cell cycle arrest, apoptotic and autophagic pathways in a variety of cancer cells including those of colorectal carcinoma.14, 15, 16, 17 Previous studies have indicated that various factors, including Akt, ERK, FAS, ROS, NF-κB, PI3K, and RTK, were involved in the anticancer activity of oridonin.17, 18, 19 Although various mechanisms were proposed to explain the anticancer activity of oridonin, most of the research has been scattered. This evidence concerns the gene AKT1 and cancer.