To verify this hypothesis, we first analyzed various proteins, including the GLUT1 and MCT1, which have been reported to be major regulators of the glucose supply and lactate export in colorectal carcinoma.23, 24 The results showed that the GLUT1 and MCT1 protein levels were downregulated following oridonin treatment for 24 h in a dose-dependent manner (Figure 3a). Here, SLC2A1 is linked to colorectal carcinoma.