SLC2A1 and colorectal carcinoma: GLUT1 is one of the most important regulators of glucose import, shows variable levels in many tissues and is believed to be responsible for basal glucose uptake,24 whereas MCT1 plays a major role in transport of lactate, pyruvate, and other short-chain monocarboxylates across the membrane in a freely reversible manner.43 Thus, our results indicated that oridonin can block both energy supply and lactate export through the regulation of GLUT1 and MCT1 in CRC cells.