DROSHA and cancer: It is a member of the RNase III family of endoribonucleases and targets precursor miRNA (pre-miRNA) or long double-stranded RNA (dsRNA) to produce miRNA or siRNA as part of its essential role in various RNA interference (RNAi) pathways.7, 8 Dicer is known to regulate methylation of CpG island in mammalian cancer cells;9, 10, 11, 12 however, the underlying mechanisms of the same are not clear.