SFRP1 and cholangiocarcinoma: The results of the present study indicates that Dicer translocates to nucleus and interacts with HP1α/H3K9me3/SUV39H1/Dnmts complex for effecting H3K9 trimethylation and DNA methylation at SFRP1 promoter, which results in transcriptional silencing in CCA cells (Figure 5).