Amongst these, SFRP1, an antiproliferative tumor suppressor gene located at 8p11.2, is inactivated because of aberrant promoter hypermethylation observed in numerous cancers, such as colorectal cancer17 and ovarian cancers.18 We investigated whether Dicer could regulate the chromatin modifications of SFRP1 promoter. This evidence concerns the gene SFRP1 and cancer.