CHM and non-small cell lung carcinoma: The association of mutation-induced hyperactivation of EGFR with malignant lung cancer is well established.5 Therefore, we investigated the effects of REP1 knockdown on cell growth in other NSCLC cell lines, including H2030 cells and H1975 cells, expressing wild-type EGFR and mutant EGFR (L858R and T790M), respectively.