It has been reported that Rab5A depletion in cancer cells delays EGFR degradation, but Rab5A overexpression increases EGFR degradation via acceleration of EGFR trafficking.45 Rab7 knockdown blocks constitutive recycling of non-ligand-bound EGFR to the cell surface due to accumulation in the late endosome.46 It is probable that increased Rab5 and decreased Rab7 levels might block EGFR recycling but enhance EGFR degradation in the REP1 knockdown cells. Here, CHM is linked to cancer.