Inversely, SIRT4 can function as a tumour suppressor and reduced expression is associated with several cancers.22, 61 Furthermore, Sirt4-deficient mice spontaneously develop lung tumours.24 Many cancer cells heavily depend on glutaminolysis to couple bioenergetics to redox balance, supporting cell survival.54, 62 The LSD1-directed control of glutamine anaplerosis offers an explanation for the abatement on tumour progression by LSD1 inhibitors in cancers. This evidence concerns the gene KDM1A and neoplasm.