The NF-κB-inducing activity of both wt- and psoriasis-linked CARMA2sh mutants requires BCL10, as assessed by experiments based on shRNA-mediated depletion of BCL10 (Figure 3a, left panel) and disruption of the BCL10 locus through CRISPR/Cas9/sgRNA technology in HEK293T cells (Figure 3a, right panel). Here, BCL10 is linked to psoriasis.