Most of the psoriasis-linked CARMA2sh mutants enhance the transcriptional activity of NF-κB,6, 7, 8, 9, 11 which catalyzes transcription of inflammatory mediators and plays a significant role in the progression of the disease.25 Thus, we tested the effect of ULK2 on the NF-κB-inducing activity of CARMA2sh. Here, NFKB1 is linked to psoriasis.