LGALS4 and psoriasis: Most of the studies conducted to elucidate the functional role of CARMA2 and its mutated forms associated with psoriasis have been carried out using CARMA2sh,6, 7, 8, 9, 11 the prominent isoform of CARMA2 expressed in the human skin.7, 10 Thus, to search for functional regulators of CARMA2sh we performed a yeast two-hybrid screen using as a bait CARMA2sh fused to the GAL4 DNA-binding domain.