ANGPTL4 has an important role in cancer, especially in tumor metastasis, but little is known about its function in HCC metastasis.31 The induction of ANGPTL4 by TGF-β via the SMAD signaling pathway activates cancer cells for metastasis to the lungs in breast cancer.31 In our study, we found that ANGPTL4 mRNA expression was significantly correlated with TGF-β1 mRNA after galunisertib treatment in responders, and in HCC patients, plasma ANGPTL4 protein levels were significant higher than in controls. This evidence concerns the gene ANGPTL4 and hepatocellular carcinoma.