Only one study so far investigated the expression of SKIL in 32 HCC tissues, but the authors did not find any role for this gene.27 On the contrary, in our study we significantly expanded the number of patients investigated at mRNA and plasma protein levels and we report a robust positive correlation of SKIL and TGF-β1 mRNA expression in HCC tumor samples. This evidence concerns the gene SKIL and hepatocellular carcinoma.