Recent studies have shown that Skp2 E3 ligase activity can promote p27 degradation to prevent p27-induced cell cycle arrest.30, 32, 33 Therefore, we hypothesized that simvastatin may inhibit Skp2 to promote p27 accumulation and G0/G1 cell cycle arrest in HCC cells. Here, SKP2 is linked to hepatocellular carcinoma.