LGR5 and gastric cancer: In particular, mutations in the Apc gene were found in approximately 85% of colorectal cancer cases [15], and activating β-catenin mutations that affect its phosphorylation by Gsk3β, have been identified in 50% of colon cancers that have wild-type Apc. Considering that the stomach and intestine share the same origin during development, and their adult stem cells express the same specific marker (Lgr5), it is likely that the Wnt signaling pathway has similar impacts on the development of gastric cancer and the development of colorectal cancer.