This transcriptional switch was linked to an increase in both CYCLIN D1 and TP53 and the induction of a chaotic cellular environment associated with cholestasis that features both increased apoptosis (that may be associated with increased TP53) and proliferation (that may be driven in part by increased CYCLIN D1) from which tumors emerge [20,58]. This evidence concerns the gene CCND1 and cholestasis.