MYC and neoplasm: In the context of tumor formation, reduced MNT expression as a response to hypoxia is predicted to, among other things, relieve repression at target genes shared with MYC (and potentially with HIF factors) and therefore aid the expression of transcriptional programs governed MYC and HIF factors that reprogram metabolism to support glucose uptake and glycolysis utilized for macromolecule biosynthesis and proliferation in a low oxygen environment [57].