Thus, while loss of MNT and mild MYC overexpression act similarly to generate a balance of apoptosis and proliferation that is ultimately favorable for tumor formation, when combined, the balance is shifted steeply toward apoptosis and appears to be analogous to when MYC expression is driven above a certain threshold level to where apoptosis becomes the dominant outcome and tumor formation is abrogated [50]. The gene discussed is MYC; the disease is neoplasm.