CYP4Z1 and breast carcinoma: In human mammary carcinoma, CYP4Z1 which considered a novel CYP4 is over-expressed and was found to be associated with high-grade tumors and poor prognosis, in addition, stable expression of CYP4Z1 in T47D human breast cancer cells lead to higher contents of 20-HETE, whereas HET0016 potently inhibited the tumor-induced angiogenesis with associated changes in the intracellular levels of 20-HETE [213].