In T2D and CVD patients, not only a similar lipoprotein profile, but also impaired HDL-mediated cholesterol efflux and antioxidant function74, 75, 76, 77, and a reduced expression of ABCG1 on monocytes is found, the latter which is described to lead to an increase in cellular cholesterol accumulation78. This evidence concerns the gene ABCG1 and type 2 diabetes mellitus.