In addition, genetic reduction in the level of the NF‐κB subunit p65/RelA in Ercc1−/∆ mice, with a lifespan 6 months, delayed the onset of age‐related pathology including osteoporosis, neurodegeneration, BM hypoplasia, epidermal atrophy, sarcopenia, liver and kidney dysfunction. This evidence concerns the gene RELA and osteoporosis.