The expression of the gene encoding for the HIF-1β (ISCW023999), which is a molecular partner of HIF-1α, was up-regulated in midguts from infected ticks, but was down-regulated in nymphs and did not change in salivary glands and ISE6 cells in response to infection (Ayllón et al., 2015; Villar et al., 2015). The gene discussed is HIF1A; the disease is infection.