Using the appropriate bioinformatics tools and the PAM method to obtain 100 repeated samplings, we identified 10 candidate genes that are significantly associated with CRC (ABCG2 AQP8, SPIB, CA7, CLDN8, SCNN1B, SLC30A10, CD177, PADI2 and TGFBI). The gene discussed is PADI2; the disease is colorectal carcinoma.