SPIB and hepatocellular carcinoma: Takagi et al. (2016) revealed that SPIB expression is a novel indicator of poor prognosis in patients with diffuse large B-cell lymphoma and mediates apoptosis through the PI3K-AKT pathway. Furthermore, Ho et al. (2016) reported that high SPIB and KI-67 mRNA expressions levels were associated with poor survival in patients with hepatocellular carcinoma.