Using the appropriate bioinformatics tools and the PAM method to obtain 100 repeated samplings, we identified 10 candidate genes that are significantly associated with CRC (ABCG2 AQP8, SPIB, CA7, CLDN8, SCNN1B, SLC30A10, CD177, PADI2 and TGFBI). Here, CD177 is linked to colorectal carcinoma.