ANXA5 and ischemia: Many diseases are related to the activity of this protein including different types of malignancies, complication of pregnancy, cardiovascular disease, systemic lupus erythematosus, and Ischemia (27-29).  Many kinds of cancers such as pancreatic adenocarcinoma, sarcoma, tumorigenesis and progression of breast cancer and prostate cancer stem cells are linked to Annexin A5 (Anxa5) activity, but its contribution is different in variety of malignancies.