Moreover, the treatment with rapamycin significantly decreased the migration rate (Figure 7B), proliferation (Figure 7C); and COL1A1 expression (Figure 7D) and restored the levels of SM-MHC, and SM-calponin (Figure 7D) in HPASMC incubated with PDGF or SSc IgG. Here, COL1A1 is linked to systemic sclerosis.