In tumor microenvironment, many inflammatory cytokines, such as interleukin (IL)-6 (1), granulocyte colony-stimulating factor (G-CSF) (2), interferon (IFN)-α (3), IFN-γ (4), and leptin (5), contribute to tumorigenesis by promoting tumor growth and invasion. The gene discussed is CSF3; the disease is neoplasm.