SOCS1 and non-small cell lung carcinoma: In non-small cell lung cancer cells, SOCS-1 inhibits the activity of FAK-dependent signaling pathway, except for JAK/STAT signaling, by suppressing the phosphorylation of FAK tyrosine (32, 33) and promoting polyubiquitination and the degradation of FAK in a SOCS box-dependent manner (21).