Therefore, although few references have reported that miRNA-induced dysregulation of SOCS expression and function exerts significant influence on the clinical outcome of cancer patients, some miRNAs, such as miR-155, miR-19a, miR-19b, and miR-221, might be promising biomarker candidates in predicting and evaluating the clinical prognosis of certain tumor types. This evidence concerns the gene CISH and cancer.