SOCS3 and hepatocellular carcinoma: Additionally, the knockdown of p53 and PTEN in MCF10 cells promotes the downregulation of SOCS3 at translational/posttranslational level; such action is attributed to the proteasomal degradation after the activation of proinflammatory IL-6/STAT3/NF-κB signaling pathway rather than DNA methylation in colorectal and hepatocellular carcinomas (9, 48).