Neither were effects of Brugada syndrome-linked mutations in Kv4.3 (KCND3; Giudicessi et al., 2011), KCNE3 (Delpón et al., 2008) and KCNE5 (Ohno et al., 2011) quantified here in the context of isoform-specific effects, but it will be interesting to investigate potential differences in the future. The gene discussed is KCNE5; the disease is Brugada syndrome.