Pulmonary❖ Seen after 8–14 weeks of 1st dose of ipilimumab.❖ Asymptomatic appearance of infiltrates on lung imaging is more common.❖ Symptomatic pneumonitis is seen in =1%. More common with anti-PD-1/anti-PD-L1 than anti-CTLA-4 therapy. The gene discussed is CD274; the disease is pneumonitis.