To further confirm that CRT0066101 did not enhance the IFN response, we examined the induction of 2′-5-oligoadenylate synthetase (OAS), as a marker of interferon-stimulated gene (ISG) induction, in HeLa cells infected with HRV16 in the presence of CRT0066101 20 h following infection with live virus. This evidence concerns the gene SMOC1 and infection.