PRDM16 and cardiomyopathy: The 1p36 deletion syndrome can be associated with cardiomyopathy, and the PRDM16 gene (which encodes a transcription factor) has been identified as a possible cardiomyopathy gene at this locus, linked with a syndromic cardiomyopathy as well as with adult-onset DCM (in 5 out of 131 individuals with four novel missense variants) [51].