Evaluation of FLNC variants in a large (n = 2877) cohort of patients with inherited cardiac diseases, including DCM, has shown that the phenotype of individuals with truncating variants in FLNC is notable for left ventricular dilation, systolic impairment, ventricular arrhythmias, cardiac fibrosis, and sudden cardiac death [65]. This evidence concerns the gene FLNC and familial dilated cardiomyopathy.