The CLCNKA gene, encoding the renal ClC-Ka chloride channel, is in high LD with HSPB7. A common SNP (rs10927887) in CLCNKA is associated with both ischemic and non-ischemic heart failure and increased risk of heart failure (odds ratio 1.27 per allele copy) [42]. This evidence concerns the gene HSPB7 and heart failure.