INS and obesity due to melanocortin 4 receptor deficiency: A significant positive association has also been found between BMI and insulin, HOMA-IR values and BMI, HOMA-IR values and WC as well as HOMA-IR values and TG among children and adolescents 6,33, thus further corroborating the results of the present study, which show a three-fold greater probability of obesity associated with increased insulin levels and HOMA-IR values.