Although the leptin levels in patients with fibromyalgia and overweight/obesity were lower than those in participants in the control group with overweight/obesity, when we compared patients with fibromyalgia with overweight/obesity with those with normal weight we found a trend towards higher unadjusted leptin levels in the overweight/obesity group (14,715.00 ± 8,884.65 pg/mL versus 10,578.00 ± 7,906.84 pg/mL; p = 0.05). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.