However, the serum concentration of IL-18 showed significant differences between groups (F=24.18, P=0.000); the sJIA group showed a significantly higher IL-18 level than the normal control group (81,269±24,105 vs 1,930±302 pg/mL, P=0.000), ALL group (11,824±9,168 pg/mL, P=0.000), SIF group (5,643±1,935 pg/mL, P=0.000), KD group (4,985±2,170 pg/mL, P=0.000), and JIA group (1,818±644 pg/mL, P=0.000). Here, IL18 is linked to acute lymphoblastic leukemia.