CD68 and obesity due to melanocortin 4 receptor deficiency: HFD-induced obesity was associated with increased expression of inflammatory markers CD68 and F4/80 (CH vs. CC, P < 0.05, HH vs. CC, P < 0.01, CH-STZ vs. CC, P < 0.01, HH-STZ vs. CC, P < 0.001, Fig 7A–7D).