In fact, Sathler-Avelar et al. [31,36,37] suggested that the establishment of a type 1-modulated immune profile, with IFN-γ-mediated pro-inflammatory response together with high levels of IL-10 are key elements for parasite clearance in the absence of deleterious tissue damage that eventually might occur during Chagas disease treatment. The gene discussed is IFNG; the disease is Chagas disease.