Additionally, the mutations in MT-RNR1 gene and MT-TS1 gene, encoding 12S rRNA and the transfer RNA for serine, respectively, are major contributors to NSHL or aminoglycoside-induced deafness, which may have an effect of increasing susceptibility to aminoglycoside ototoxicity11, 12. Here, MT-RNR1 is linked to nodular sclerosis classical Hodgkin lymphoma.