TSC1 and allergic asthma: In view of these findings, we inferred that Rheb1 as a downstream effector of the TSC1/2 complex can directly participate in regulating macrophage polarization and influencing OVA-induced allergic asthma by reorganizing Th1/Th2 cytokine expression, which may be dependent on the TSC–mTORC1 signaling pathway.