As shown in Fig. 6a–d, in the control group, the mRNA expressions of M2 markers such as Arg1, Fizz1, IL-10 and Ym1 in Rheb1-KO mice were greatly enhanced compared with those in WT mice, while in contrast, differences in mRNA expressions of M2 markers were more significant between Rheb1-KO mice and WT mice in the asthma group. The gene discussed is IL10; the disease is asthma.