REN and Insulin resistance: Recent researches have demonstrated that traditional Chinese medicinal herbs and formulas with kidney yin-tonifying effect display good clinical antihypertensive efficacy and its underlying multiple cardiovascular protective mechanisms might be relevant to inhibiting the activity of sympathetic nerve, blocking the renin-angiotensin system, improving endothelial function, preventing target organ damage, inhibiting inflammation, and improving insulin resistance as well as glucose and lipid metabolism23, 36, 37.