Subsequently to the identification of PerC in EPEC, five pch genes were identified in E. coli O157:H7, a serotype causing hemorrhagic colitis, along with the serious complication known as hemolytic uremic syndrome, or HUS (Frankel et al., 1998; Nataro and Kaper, 1998; Ogura et al., 2006). This evidence concerns the gene PPARGC1B and hemolytic-uremic syndrome.