MAP2K1 and infection: We found that the HA-membrane accumulation promoted the level of MEK1 phosphorylation and decreased the level of MEK1 SUMOylation at 1 h post infection, and the level of MEK1 SUMOylation reached a valley and the level of MEK1 phosphorylation reached a peak at 2 h post infection (Figure 5A and Figure S3).