Contrast with our findings, recently, Jain D et al. [38] reports DJ-1 deletion induced glucose intolerance due to reduced islet beta cell and levels of insulin in 12–13 weeks old or 8 weeks old plus 2 weeks of HFD, In our study, glucose tolerance tests were performed from 3 months to 12 months old age, and we found that DJ-1 KO exhibits age-dependent glucose tolerance, although as DJ-1 Tg mice developed the age-dependent glucose intolerance due to alterations in BAT activity. This evidence concerns the gene INS and Glucose intolerance.