APOE, TTR, CLU and APOA1 as related hub proteins of cirrhosis and TTR, CLU, APOA1, TFRC, VWF, CKAP5, A2M, ZNF648, mCASP8, HSP27 as hub proteins of HCC are highlighted in figure 1 and tabulated in table 3. The gene discussed is CLU; the disease is hepatocellular carcinoma.