APOE, TTR, CLU and APOA1 as hub protein are introduced for cirrhosis and TTR, CLU, APOA1, TFRC, VWF, CKAP5, A2M, ZNF648, CASP8 and HSP27 (HSPB1) are the related hub proteins to HCC. This evidence concerns the gene CASP8 and hepatocellular carcinoma.