APOE, TTR, CLU and APOA1 as hub protein are introduced for cirrhosis and TTR, CLU, APOA1, TFRC, VWF, CKAP5, A2M, ZNF648, CASP8 and HSP27 (HSPB1) are the related hub proteins to HCC. Here, VWF is linked to hepatocellular carcinoma.